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產(chǎn)品名稱

C5L2, Rat Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HP8018

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	C5L2, Rat
Clone	polyclonal
Host Species	Rabbit
Reactive Species	rat
Isotype	n/a
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	FC, functional studies
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The polyclonal antibody reacts with rat C5L2. The orphan receptor C5L2 is a seven transmembrane receptor with 40% amino acid sequence identity to the C5a receptor, CD88. Expression has been found on granulocytes and immature dendritic cells. In contrast to CD88, C5L2 is uncoupled from G proteins due to an an amino acid replacement of arginine by leucine in the so called DRY region at the end of the third intracellular transmembrane domain. Following C5a binding, C5L2 seems neither to induce classical signalling nor to cause biological responses. When C5L2 was transfected into several cell types, C5a failed to induce chemotaxis, degranulation, or interacellular calcium mobilization. The high affinfity of C5L2 for C5a and its metabolite, C5adesArg and a low affinity for C3a and C3adesArg suggest that this receptor is a scavenger of complement fragments involved in the defence against the harmful side effects of complement activation. C5L2 expression on human neutrophils is known to be decreased in sepsis; loss of expression may be a prognostic indicator in this condition as survivors of sepsis tend to have higher C5L2 levels.
Immunogen	n/a
Other Names	n/a
Gene, Accession #	n/a
Catalog #	HP8018
Price
Order / More Info	C5L2, Rat Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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