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產(chǎn)品名稱

Coagulation factor XII, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號

HM2322

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Coagulation factor XII, Human
Clone	13820
Host Species	Mouse
Reactive Species	human, mouse
Isotype	IgG2a
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	immunoassay, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Monoclonal antibody 10-11-37 recognizes Coagulation Factor XII (FXII, Hageman factor). FXII is a serine protease and plays a role in blood coagulation, fibrinolysis, kinin and complement systems. The protein is the zymogen of the serine protease factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced by contact to charged surfaces, also known as the plasma contact system. FXII is predominantly synthesized in the liver and is composed of fibronectin type I and II domains, two epidermal growth factor-like domains, a kringle region, a proline-rich domain and a catalytic domain. Its molecular weight is approximately 80kDa on SDS-PAGE gel electroforeses. The protein circulates in the plasma at a concentration of 30-35 μg/ml. FXII forms the plasma contact system together with high molecular weight kininogen and plasma kalikrein. FXII autoactivates when these three proteins form a complex on negatively charged nonphysiological surfaces, like inorganic surfaces (eg silicon tubes) or macromolecular organic surfaces (eg heparin) bound to the surface of different cell types, including endothelial cells, platelets and neutrophils. It can trigger blood coagulation and generation of proinflammatory bradykinin. After surface complexation, XFII autoactivates into FXIIa, also called factor XII fragment(XIIf). Once small amounts of kalikrein are formed a positive feedback loop is active leading to enhanced conversion into XFIIa. The activation leads to a series of active enzyme formation. FXIIa converts prekallikrein to kallikrein and kallikrein digests kinogen to liberate proinflammatory bradykinin. Bradykinin triggers inflammatory reactions via activating endothelial cells resulting in vasodilatation, increased vascular permeability and production of other mediators like nitric oxide. The contact system has the ability to activate the complement system via the classical pathway. Simultaneous activation of both systems may lead to pathological conditions, like hereditary angioedema in individuals with dysfunctional C1-inhibitor (C1-IHB). FXIIa can activate complement protein C1r and to a lesser degree C1s in absence of C1-IHB. This leads to unimpeded bradykinin formation resulting in angioedema. Other interactions with complement system are found on the level of gC1qR and MASP-1. The antibody is specific for the heavy chain of FXIIa.
Immunogen	FXII adsorbed onto Al(OH)3 adjuvant and emulsified in Freund's Incomplete Adjuvant
Other Names	FXII, Hageman factor
Gene, Accession #	n/a
Catalog #	HM2322
Price
Order / More Info	Coagulation factor XII, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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