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產(chǎn)品名稱

TNF-RI, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM2021

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

50 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	TNF-RI, Human
Clone	H398
Host Species	Mouse
Reactive Species	human, rat
Isotype	IgG2a
Format	biotin conjugate
Size	50 μg
Concentration	100 μg/ml
Applications	FC, functional studies, immunoassay, IP, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody H398 recognizes the extracellular part of the Tumor Necrosis Factor Receptor type I (TNF-RI) of the membrane-bound as well as the soluble receptor. TNF-RI (~55-60 kDa) is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. TNF-alpha activates inflammatory responses, induces apoptosis, regulates cellular proliferation, and may even promote cancer progression. The effects of TNF-alpha are mediated by TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. Induction of cytotoxicity and other functions are mediated largely via TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is efficiently activated only by the membrane bound form of TNF-alpha. TNF-RI signaling is initiated when trimeric TNF-alpha binds TNF-RI receptors. Subsequent TNF-RI trimerization promotes the recruitment of a proximal signaling complex composed of TNF Receptor Associated protein with a Death Domain (TRADD), Receptor Interacting Protein (RIP), cellular Inhibitor of Apoptosis Protein 1 (cIAP1), TNF Receptor Associated Factor 2 (TRAF2), and likely TRAF5. Studies with TNF-RI-deficient mice indicate that TNF-RI mediates most of the proliferation, pro-inflammatory, and apoptosis-activating pathways.
Immunogen	Affinity-purified receptor material from HL60 cells containing ~9 μg actively binding receptor (Ref.1).
Other Names	CD120a, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, p55, p60, TNFR-1.
Gene, Accession #	TNFRSF1A, TNFAR, TNFR1
Catalog #	HM2021
Price
Order / More Info	TNF-RI, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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