| 產(chǎn)品詳情 |
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| Antigenic Specificity | VAP-1, Mouse |
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| Clone | 7-88 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b |
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| Format | unconjugated |
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| Size | 100 μg |
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| Concentration | 100 μg/ml |
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| Applications | frozen sections, FC, functional studies, IF, IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody 7-88 recognizes mouse Vascular Adhesion Protein-1 (VAP-1) which- is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It contains a short N-terminal cytoplasmic tail, a single membrane-spanning domain and a large extracellular part. A soluble form of VAP-1 (sVAP-1) has been described, which presumably results from the proteolytic cleavage of membrane-bound VAP-1. Structurally VAP-1 belongs to enzymes called semicarbamizide-sensitive amine oxidases, which contain copper as a cofactor. These enzymes deaminate primary amines in a reaction producing hydrogen peroxide, aldehyde, and ammonia. VAP-1 is expressed in endothelial cells, smooth muscle cells, adipocytes, and in follicular dendritic cells. In endothelial cells the majority of VAP-1 is stored within intracellular granules and translocated to the surface upon inflammation where it regulates leukocyte tissue infiltration. Furthermore, the end-products formed by VAP-1 can also regulate leukocyte migration by signaling effects, have insulin-like effects in energy metabolism, and can cause vascular damage by direct cytotoxicity. In- white adipose tissue of obese and diabetic db-/- mice increased expression of VAP-1 has been observed suggesting that it contributes- to the arthrosclerosis and vascular dysfunction observed in these diseases. Moreover, inhibition of VAP-1reduced the accumulation of myeloid cells into tumors and attenuates tumor growth. The monoclonal antibody 7-88 inhibits migration of granulocytes and monocytes in acute models of inflammation. |
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| Immunogen | Vessels from mouse lymph nodes |
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| Other Names | Amine oxidase copper containing 3; AOC3; SSAO;- membrane copper amine oxidase |
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| Gene, Accession # | n/a |
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| Catalog # | HM1094 |
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| Price | |
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| Order / More Info | VAP-1, Mouse Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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