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產(chǎn)品名稱

ZO-2, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號

HP9046

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	ZO-2, Human
Clone	polyclonal
Host Species	Guinea
Reactive Species	human, mouse
Isotype	n/a
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, IF, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The polyclonal antibody recognizes human zona occludens 2 (ZO-2), an ~160 kDa tight junction protein belonging to the membrane-associated guanlyate kinase (MAGUK) family. Members of this family are involved in epithelial and endothelial intercellular junctions. They each contain at least one PSD95/Dlg/ZO-1 (PDZ) domain, a Src homology 3 (SH3) domain, and an enzymatically inactive guanylate kinase domain. PDZ domains are 90-amino acid protein-protein binding domains that recognize at least a 3-residue peptide motif in the COOH termini of their binding partners. PDZ domain-containing proteins, like ZO-2, typically act as scaffolding proteins that organize membrane receptors and cytosolic proteins into multimeric signaling complexes often at the sites of cell-cell contact. The effectiveness and stability of the epithelial barrier depends on a complex of proteins composing different intercellular junctions, which include tight junctions, adherens junctions, and desmosomes. ZO-2 can interact with zona occludens 1 (ZO-1). Furthermore, the PDZ2 domain of ZO-2 was shown to interact with connexin-43, the predominant connexin in epithelial and most other tissues which is involved in cell growth control and embryonic development. For immunisation of the guinea pig, amino acids 411-467 of human ZO-2 were used as immunogen. The antibody cross reacts with mouse ZO-2.
Immunogen	n/a
Other Names	Tight junction protein 2 (TJP2)
Gene, Accession #	n/a
Catalog #	HP9046
Price
Order / More Info	ZO-2, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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