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產品名稱

LL-37/CAP-18, Human Antibody from HYCULT BIOTECH

產品貨號

HM2071

產品價格

現貨詢價，電話：010-67529703

產品規(guī)格

100 μg

產品品牌

HYCULT BIOTECH

產品概述

產品詳情

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Antigenic Specificity	LL-37/CAP-18, Human
Clone	1-1C12
Host Species	Mouse
Reactive Species	human
Isotype	IgG2a
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	immunoassay, IF, paraffin sections, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody 1-1C12 recognizes free LL-37 as well as its precursor human CAP18 (hCAP18). hCAP18 is a cathelicidin protein of ~18 kDa. It belongs to the cathelicidin family of antimicrobial peptides that are characterized by a conserved N-terminal cathelin domain and a variable C-terminal antimicrobial domain. Cathelicidins are predominantly found in the peroxidase-negative granules of neutrophils. During bacterial infections, the life span of neutrophils is regulated by various pathogen- and host-derived substances. Within the neutrophils, the cathelicidins are synthesized as preproproteins. After removal of the signal peptide,they are stored in granules as inactive proforms. The C-terminal antimicrobial peptides are activated when cleaved from the proforms of the cathelicidins by serine proteases from azurophil granules. hCAP18 is a major protein in specific granules of neutrophils, but it is also present in subpopulations of lymphocytes and monocytes, in squamous epithelia (of the mouth, tongue, esophagus, cervix, and vagina), pulmonary epithelium, keratinocytes in inflammatory skin diseases and in the epididymus. The antibacterial C-terminus of hCAP18, LL-37 (37 amino acids), has been shown to exert broad antimicrobial activity towards gram-negative as well as gram-positive bacteria and to have synergistic antibacterial effects with the defensins. For instance deficiency in saliva, LL-37 accords with occurrence of periodontal disease in patients with morbus Kostmann. LL-37 does not only kill bacteria, but can also modulate (suppress) neutrophil apoptosis via the activation of FPRL1 and P2X7 in bacterial infections. Suppression of neutrophil apoptosis results in the prolongation of their life span, and may be advantageous for host defense against bacterial invasion. Moreover it functions as a chemotactic agent for neutrophils, monocytes and T cells. LL-37 is markedly resistant to proteolytic degradation and to a limited extent also cytotoxic towards mammalian cells.
Immunogen	mixture of synthetic native and glutaraldehyde cross-linked LL-37<sup>1sup>
Other Names	Antibacterial protein LL-37, Cathelicidin antimicrobial peptide CAP18; CRAMP; FALL-39; FALL39;- CAP-18; hCAP-18; HSD26
Gene, Accession #	n/a
Catalog #	HM2071
Price
Order / More Info	LL-37/CAP-18, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產品資料

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