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產(chǎn)品名稱

LL-37/CAP-18, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號

HM2070

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	LL-37/CAP-18, Human
Clone	3D11
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	functional studies, IF, paraffin sections, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Cationic antimicrobial peptides, such as cathelicidins play important roles in the defense against infections by eliminating a wide range of pathogens. hCAP-18/LL-37 is the only cathelicidin identified in humans and it is produced by neutrophils, monocytes, mast cells, and epithelial cells. It is stored in these cells as a propeptide, which can be cleaved extracellularly by enzymes like proteinase 3, resulting in the formation of LL-37 and a cathelin part. LL-37 is an amphipathic a-helical peptide that can affect both planktonic bacteria and those residing in biofilms, viruses such as HIV and fungi, and it can neutralize LPS and lipoteichoic acid (LTA). In addition to its antimicrobial actions, LL-37 participates at the interface of innate and adaptive immunity by modulating cytokine and chemokine production by a range of cell types, chemoattracting various immune effector cells and mesenchymal stem cells, regulating autophagy in conjunction with vitamin D, and stimulating angiogenesis and wound healing. LL-37 does not only kill bacteria, but can also modulate (suppress) neutrophil apoptosis via the activation of FPRL1 and P2X7 in bacterial infections. Suppression of neutrophil apoptosis results in the prolongation of their life span, and may be advantageous for host defense against bacterial invasion. Moreover, it functions as a chemotactic agent for neutrophils, monocytes and T cells. LL-37 is markedly resistant to proteolytic degradation and to a limited extent also cytotoxic towards mammalian cells. The antibody detects both free LL37 (MW 4 kDa)and complete hCAP18 (MW 19 kDa). The monoclonal antibody 3D11 can be used for neutralizing the function of LL-37. The ability of mast cells to kill pneumococci was significant attenuated using the monoclonal antibody 3D11.
Immunogen	Human LL-37 peptide
Other Names	Cathelicidin antimicrobial peptide, hCAP-18, Antibacterial protein LL-37, Cap-18, CRAMP; HSD26; FALL39; FALL-39; CAMP
Gene, Accession #	n/a
Catalog #	HM2070
Price
Order / More Info	LL-37/CAP-18, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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