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產(chǎn)品名稱

Mannose receptor, Mouse Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM1049

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Mannose receptor, Mouse
Clone	MR5D3
Host Species	Rat
Reactive Species	mouse
Isotype	IgG2a
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, FC, functional studies, immunoassay, IF, IP, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody MR5D3 recognizes the Mannose Receptor (MR, also known as CD206), a member of the vertebrate C-type lectin family. MR is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 175 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain and an intracellular carboxy-terminal tail.The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. Moreover, the MR has also been shown to bind and internalize tissue-type plasminogen activator. MR’s are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines such as IL-4. Labelling of MR expressing monocytes/macrophages increases with prolonged incubation time probably due to internalization of the MR-antibody-complex. Detection of the MR with anti-MR monoclonal antibody MR5D3 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific.
Immunogen	Chimaeric CRD4-7-Fc protein
Other Names	CD206, MMR, cLEC13D, Macrophage mannose receptor 1
Gene, Accession #	n/a
Catalog #	HM1049
Price
Order / More Info	Mannose receptor, Mouse Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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