| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | C5/C5a, Human |
|---|
| Clone | 561 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG2a |
|---|
| Format | unconjugated |
|---|
| Size | 100 μg |
|---|
| Concentration | 100 μg/ml |
|---|
| Applications | functional studies, immunoassay |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Monoclonal antibody 561 recognizes the N-terminus of C5. The antibody reacts both with intact C5 (190 kDa) as with C5a (115 kDa). The complement system is composed of over 30 proteins, activated in response to tissue injury, invading pathogens or other foreign surfaces. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5 into C5a and C5b, resulting in activation of the lytic pahway. C5a was first described as a cleavage product of C5 with chemotactic and anaphylatoxic properties. Further characterization revealed that C5a is an essential part of the innate immune response and evidence now suggests that it may also play a role in adaptive immunity. Complement fragment C5a is a 74 residue pro-inflammatory polypeptide. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. C5a binds to at least two seven-transmembrane domain receptors, C5aR (C5R1, CD88) and C5L2 (gpr77), expressed ubiquitously on a wide variety of cells but particularly on the surface of immune cells like macrophages, neutrophils and T cells. The former is a well-established receptor that initiates G-protein-coupled signaling via mitogen-activated protein kinase pathways, thereby by inducing synthesis of cytokines such as TNF-alpha, IL-1beta,- IL-6 and IL-8. Its in vivo blockade greatly reduces inflammatory injury. Much less is known about C5L2, occupancy of which by C5a does not initiate increased intracellular Ca(2+).The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases. Nowadays C5a is also implicated in non-immunological functions associated with developmental biology, CNS development and neurodegeneration, tissue regeneration, and haematopoiesis. |
|---|
| Immunogen | Human C5/C5a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HM2076 |
|---|
| Price | |
|---|
| Order / More Info | C5/C5a, Human Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
欧美成人三级片网站,91调教在线,国产一级特黄大片做受
|
国产 日韩 欧美,捏胸吃奶吻胸免费视频大软件,国产欧美日韩精品在线观看
|
国产一区二区免费在线观看,韩国少妇激三级做爰,抽插亚洲
|
99精品一区二区,成人A片一级,中日韩在线视频
|
岛国视频在线观看,国产videos麻豆丝袜老师,高潮是mamamama的韩文歌
|
五月天婷婷色综合,男女性生活一级片,婷婷久久99
|
国产精品无码一区二区三区喝尿,男人舔女人下部高潮全视频,天天爱天天草
|
老妇人一区二区三区,娇女嗯啊好猛h古代将军安软软,国产操逼视频91
|
99re6热在线视频精品观看,1v1粗口巨荤h,国产免费一级片
|
亚洲五月中文字幕,欧美二三四区,91无码人妻精品一区二区帝霸网
|
|