| 產(chǎn)品詳情 |
| Edit |   |
| Antigenic Specificity | C3c, Human |
| Clone | F1-4 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 100 μg |
| Concentration | 100 μg/ml |
| Applications | immunoassay, IP, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Antibody F1-4 recognizes a unique epitope exclusively present on human complement C3c. The complement system mediates a number of essential biological functions that participate in host defense against infection, initiation of the inflammatory reaction, processing and clearance of immune complexes and regulation of the immune response. There are three pathways of complement activation: the classical pathway is initiated by immune complexes, the lectin pathway by surface bound mannan binding lectin and the alternative pathway by all the surfaces that are not specifically protected against it. Each of the complement pathway generates a C3 convertase, a serine protease that cleaves the central complement protein C3, and generates the major cleavage fragment C3b. C3b is an opsonin and part of one of the main convertases that drives the complement cascade. In the presence of complement regulatory molecules C3b may be further degraded sequentially to iC3b, C3c, C3dg and C3d. The disadvantage of most complement biomarkers is their short half-life, making reliable sample collection and measurements difficult. Unlike other C3 fragments, C3c does not bind to other structures, like pathogens, cell surface (receptors) and other plasma proteins. Therefore, C3c is a stable complement biomarker which will appear in the fluid phase only, without interference of other C3 based products. The measurement of C3c provides evidence of (uncontrolled) complement activation and can be used as an indicator of an inflammatory state. The complement is a key element of the innate immune system. In appropriate activation is pathologic and leads eg. To various autoimmune diseases, like HUS. There are also indications that C3 is associated with the cardiovascular system and Parkinson's disease, making C3c a reliable and useful biomarker. Antibody F1-4 only reacts with C3c and does not cross-react with other C3 fragments. The antibody can be used in ELISA, western blotting and immunoprecipitation. |
| Immunogen | Synthetic peptide representing the last 16 C-terminal (NKTVAVRTLDPERLGR) residues of C3c alpha domain 1 coupled onto PPD (purified protein derivate, Statens Serum Institut) |
| Other Names | Complement component C3, C3c |
| Gene, Accession # | n/a |
| Catalog # | HM2318 |
| Price | |
| Order / More Info | C3c, Human Antibody from HYCULT BIOTECH |
| Product Specific References | n/a |
| 產(chǎn)品資料 |
|
国产精品久久久久久久白晢女i,欧洲一级片,欧美中日韩在线
|
一级A片处破外女粉红女郎,夜夜嗨av一区二区三区网页,欧美亚洲中文字幕
|
尤物com,色妞www精品视频7777,成人 18禁视频网站在线看
|
操逼免费片,羞羞色视频,做爱视频动漫
|
欧美老妇人XXXX一区二区三区,大奶久久,久久精品久久久精品美女
|
国产精品福利在线观看,宝贝屁股翘起来浪一点,老鸭窝黄色
|
99热在线观看精品免费,久久久久久国产精品三级玉女聊斋,操BXXXXX
|
美女扒开腿秘 让人桶爽,主人隔着内裤揉我下面h,a视频在线观看免费
|
亚色91,美女和男人羞羞视频,天天好逼网综合
|
插小穴网站,中国偷窥成熟视频,人人插人人干在线观看
|
|