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產(chǎn)品名稱

TRACP5a, Human, ELISA kit from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HK363-01

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

1 x 96 det.

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	TRACP5a, Human, ELISA kit
Description	Tartrate-resistant acid phosphatase (TRACP) is a biomarker with multiple clinical and basic applications. It has long been used as a cytochemical marker to identify hairy cell leukemia cells and as a marker for differentiated cells of monocyte lineage including macrophages (M?), osteoclasts (OC), and dendritic cells (DC). The clinically relevant M?/OC/DC TRACP is called Type-5 acid phosphatase encoded by the Acp5 gene. TRACP consists of two isoforms (Type 5a and 5b) that have different biochemical properties, clinical significance and perhaps biological functions. TRACP5a circulates as a 35 kDa glycoprotein with an intact central regulatory loop peptide, which interacts with the active site. TRACP5b circulates as a disulfide linked heterodimer in which the loop peptide has been proteolytically processed to yield 16 kDa and 23 kDa fragments. Osteoclasts secrete TRACP5b during bone resorption making it a sensitive and specific serum biomarker for OC number and bone resorption rate. TRACP5a, but not 5b, is secreted by activated macrophages and dendritic cells. Elevated serum TRACP5a is emerging as a potential marker for systemic macrophages and chronic inflammation. The principal clinical application of serum TRACP immunoassay is to estimate isoform 5b activity as a marker of osteoclast number and bone resorption rate. This is done in commercial immunoassays by increasing the pH to a level selectively permissive for isoform 5b activity and / or by using a substrate selective for isoform 5b. The antibody used in this ELISA reacts with a critical epitope and binding to TRACP protein causes inactivation of the enzymatic activity. Cross Reactivity: Mouse - No , Pig - No , Rabbit - No , Rat - No
Size	1 x 96 det.
Concentration	n/a
Applications	Immunoassay
Other Names	Tartrate-resistant acid phosphatase Sandwich ELISA kit, EIA, enzyme immunoassay, assay
Gene, Accession, CAS #	n/a
Catalog #	HK363-01
Price
Order / More Info	TRACP5a, Human, ELISA kit from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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