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產(chǎn)品名稱(chēng)

AAK1 Antibody from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號(hào)

LS-C500949

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	AAK1
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human
Isotype	n/a
Format	biotin conjugate
Size	n/a
Concentration	n/a
Applications	ELISA
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	AAK1 Antibody (Biotin) LS-C500949. Specificity: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Immunogen	Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)
Other Names	AAK1, Adaptor-associated kinase 1, AP2 associated kinase 1, KIAA1048
Gene, Accession #	AAK1, Gene ID: 22848
Catalog #	LS-C500949
Price
Order / More Info	AAK1 Antibody from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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