| Description | MW: 380.91. Purity ≥98% by HPLC. ABC294640 is a specific spingosine kinase-2 (SK-2) inhibitor having antineoplastic activity. This orally available aryl admantane molecule upon administration binds and inhibits SK-2; preventing phosphorylation of the pro-apoptotic amino alcohol spingosine to spingosine-1-phosphate (S1P); the lipid mediator that is important for immunomodulation; this phosphorylation prevention of amino alcohol can induce apoptosis and may inhibit cancer cell proliferation. |
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