| 產(chǎn)品詳情 |
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| Antigenic Specificity | ORAI3 |
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| Clone | 1B4F1 |
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| Host Species | Mouse |
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| Reactive Species | human, rat |
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| Isotype | IgG2b |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Western Blot: 2 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ORAI3 Monoclonal Antibody (1B4F1). Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited |
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| Immunogen | n/a |
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| Other Names | TMEM142C; protein orai-3; transmembrane protein 142C |
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| Gene, Accession # | Entrez: 309000, 93129; Uniprot: Q6AXR8, Q9BRQ5 |
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| Catalog # | MA5-15779 |
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| Price | |
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| Order / More Info | ORAI3 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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