| 產(chǎn)品詳情 |
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| Antigenic Specificity | IRS1 |
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| Clone | 21H10L24 |
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| Host Species | Recombinant Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 4-5 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IRS1 Antibody (21H10L24), ABfinity? Rabbit Monoclonal. Insulin Receptor Substrate-1. The main function of IRS1 is to enhance growth hormone-induced proliferative signaling. The activated insulin receptor phosphorylates IRS proteins on multiple tyrosine residues that serve as docking sites for downstream mediators of metabolic actions such as phosphatidylinositol-3 kinase. IRS proteins also undergo serine phosphorylation, which regulates its function. Phosphorylation of human IRS-1 at serines, such as 312 and 616 (serines 307 and 612 in mouse), results in the impairment of metabolic insulin signaling pathways. |
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| Immunogen | n/a |
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| Other Names | HIRS-1, Insulin Receptor Substrate-1 |
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| Gene, Accession # | Entrez: 3667; Uniprot: P35568 |
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| Catalog # | 700662 |
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| Price | |
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| Order / More Info | IRS1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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