| 產品詳情 |
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| Product Name | FK-866 HCl |
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| Description | FK-866 is a selective inhibitor of the nicotinamide pathway dependent NAD+ synthesis, causing NAD+ depletion. Highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT/NAPRT) for both the substrate complex and the free enzyme (Ki=0.4 nM and Ki?=0.3 nM, respectively). NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC50=~1 nM). Causes premature senescence in normal human smooth muscle cells, an effect that may be linked to decreased activity of the NAD+-dependent enzyme SIRT1. |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | Activator or Inhibitor |
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| Other Names | NAMPT inhibitor |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P006-5MG |
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| Price | |
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| Order / More Info | FK-866 HCl from ARBOR ASSAYS, INC. |
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| Product Specific References | n/a |
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