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產(chǎn)品名稱

Granzyme B Antibody from BIOLEGEND

產(chǎn)品貨號(hào)

674603

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μl

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

Edit	&nbsp
Antigenic Specificity	Granzyme B
Clone	M3304B06
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	peroxidase (HRP) conjugate
Size	100 μl
Concentration	n/a
Applications	Western Blot (WB)
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Direct-Blot? HRP anti-Granzyme B. Granzyme B is a serine protease that is mainly produced by cytotoxic T cells (CTL) and NK cells. It plays important roles in cytotoxic lymphocyte-mediated apoptosis, chronic inflammation, and impaired wound healing. Granzyme B is packaged in cytoplasmic granules that are exocytosed towards a bound target cell, and subsequently activates multiple protein substrates to induce apoptosis. Perforin facilitates the transfer of Granzyme B into the target cell. Most circulating CD56+ CD8- NK cells and approximately half of circulating CD8+ T cells coexpress both Granzyme A and B. The activation of CD8+ and CD4+ T lymphocytes induces substantial expression of Granzyme B, but not Granzyme A. Recently, Granzyme B has been found to be produced by other cell types such as CD34+ hematopoietic progenitor cells, keratinocytes, basophils, mast cells, plasmacytoid dendritic cells, B cells, and smooth muscle cells. Elevated levels of Granzyme B are also found in some kinds of autoimmune diseases, type 1 diabetes, and cardiovascular diseases.
Immunogen	Recombinant human Granzyme B produced in the 293E cell line.
Other Names	Granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1, GZMB, CCP1, Asp-ase, CSPB, CTLA-1, CGL-1, CGL1
Gene, Accession #	Gene ID: 3002
Catalog #	674603
Price
Order / More Info	Granzyme B Antibody from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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