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產(chǎn)品名稱

c-FOS (Human) Transcription Factor Activity Assay Kit from CREATIVE BIOMART

產(chǎn)品貨號(hào)

Kit-2230

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 assays

產(chǎn)品品牌

CREATIVE BIOMART

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	c-FOS (Human) Transcription Factor Activity Assay Kit
Description	Activator protein-1 (AP-1) is a sequence-specific transcriptional activator composed of members of the Jun (c-Jun, JunB, and JunD) and Fos (c-FOS, FosB, Fra1, and Fra2) families in formats of homo- and heterodimers. These proteins belong to the bZIP group of DNA binding proteins with the ability to a common consensus sequence-defined AP-1-binding site. Inside cells, AP-1 activity is induced by an incredible diversity of signals, including growth factors, cellular stress, ionizing and ultraviolet irradiation, DNA damage, oxidative stress, neuronal depolarization antigen binding by T or B lymphocytes, and cytokines. The mechanisms involved in the induction of AP-1 activity are either through changing the expression of AP-1 components or post-translation modification or both to regulate their trans-activity positively or negatively. For example, stimulation by growth factors or by activating mutations in cytoplasmic effectors such as ras and raf, results in AP-1 activation by triggering the ERK signaling pathway. On the other hand, AP-1 responses to proinflammatory cytokines and UV radiation are mostly dependent on two other MAPK cascades, JNK and p38 of MAP kinases. As a result, the AP-1 regulates different target genes executing different biological functions such as cell proliferation, differentiation, apoptosis, or cell death. The c-FOS Transcription Factor-Activity Assay kit is a non-radioactive transcription factor assay with an ELISA format. It offers an easy, speedy, sensitive and high-throughput method to detect the activation of transcription factors.
Size	100 assays
Concentration	n/a
Applications	Detecting the c-FOS in human nuclear extraction and whole lysates.
Other Names	n/a
Gene, Accession, CAS #	n/a
Catalog #	Kit-2230
Price
Order / More Info	c-FOS (Human) Transcription Factor Activity Assay Kit from CREATIVE BIOMART
Product Specific References	n/a
產(chǎn)品資料

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