| 產(chǎn)品詳情 |
| Edit |   |
| Product Name | Cytochrome P450 2D6 Inhibitor Screening Kit |
| Description | CYP2D6 Inhibitor Screening Kit enables rapid screening of drugs and other new chemical entities (NCEs) for compound-CYP2D6 interaction in a reliable, high-throughput fluorescence-based assay. The kit provides a yeast microsomal preparation of human CYP2D6 and cytochrome P450 reductase (CPR) enzymes. The assay utilizes a non-fluorescent CYP2D6-selective substrate that is converted into a highly fluorescent metabolite detected in the visible range (Ex/Em = 390/468 nm), ensuring a high signal-to-background ratio with little interference by autofluorescence. The kit contains a complete set of reagents sufficient for performing 200 reactions in a 96-well plate format. |
| Size | 200 assays |
| Concentration | n/a |
| Applications | Rapid, high-throughput screening of drugs and novel ligands. Development of structure-activity relationship (SAR) models to predict CYP2D6 inhibition liability of novel compounds.Prediction of adverse drug-drug interaction potential and bioavailability for compounds metabolized by CYP2D6. |
| Other Names | n/a |
| Gene, Accession, CAS # | n/a |
| Catalog # | Kit-2135 |
| Price | |
| Order / More Info | Cytochrome P450 2D6 Inhibitor Screening Kit from CREATIVE BIOMART |
| Product Specific References | n/a |
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