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產(chǎn)品名稱

DC-SIGN, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號

HM2209

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	DC-SIGN, Human
Clone	DCN47.5
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	FC, functional studies
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody DCN47.5 reacts with the C-type lectin, DC-SIGN (CD209), exclusively expressed on human dendritic cells (DC). DC are specialized antigen presenting cells and bridge the innate and the adaptive immune system. They provide high levels of costimulation necessary for activation of both naive and antigen-experienced T-cells. Immature DC are capable to migrate to inflammatory sites, capture antigen and process it internally to form MHC-peptide complexes. Following antigen uptake, DC undergo maturation and migrate to lymphoid organs where they can present MHC-peptide complexes to resting T-cells and drive T-cell proliferation. During differentiation and maturation of DC, several phenotypic surface markers are expressed: CD1a, CD4, CD11, CD40, CD86, and HLA-DR. Immature DC predominantly express CCR5 which enables DC to migrate to inflammatory sites, whereas mature DC express high levels of CXCR4, a receptor that facilitates migration to lymphoid organs. DC also express DC-specific, ICAM-3 grabbing, nonintegrin (DC-SIGN), a 44 kDa C-type lectin that binds to the HIV-1 envelope glycoprotein gp120, ICAM-3 on T-cells and ICAM-2 on endothelial cells. HIV virions are able to infect cells expressing CD4 and the chemokine co-receptors CCR5 or CXCR4 and can attach to DC-SIGN to extend virion lifespan. Therefore, DC are candidates for HIV-1 infection. DC-SIGN-ICAM-3 binding is integrin-independent but calcium-dependent and antibodies reactive against DC-SIGN can be used to study DC-SIGN-ICAM3 binding. The monoclonal antibody DCN47.5 specifically reacts with the C-type lectin DC-SIGN (CD209) expressed on human dendritic cells and inhibits binding of DC-SIGN to ICAM-2 on endothelial cells.
Immunogen	Human monocyte-derived dendritic cells
Other Names	CD209 antigen, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1.
Gene, Accession #	CD209
Catalog #	HM2209
Price
Order / More Info	DC-SIGN, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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