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產(chǎn)品名稱

Dectin-1, Mouse Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM1067

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Dectin-1, Mouse
Clone	2A11
Host Species	Rat
Reactive Species	mouse
Isotype	IgG2b
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, FC, functional studies, IP
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody 2A11 recognizes mouse β-glucan receptor, also known as dectin-1. Dectin- 1 is a small type II transmembrane receptor containing one lectin-like carbohydrate recognition domain. This domain recognizes β1,3- and/or β1,6-linked glucans, intact yeast and an immunoreceptor tyrosine-based activation motif (ITAM) in the cytoplasmic tail. β-Glucan is one of the most abundant polysaccharides in fungal pathogens. By recognizing β-glucan, dectin-1 has a fundamental function in antifungal immunity. Dectin-1 is a signaling non-Toll-like pattern-recognition receptor required for the induction of protective immune responses. Dectin-1 is responsible for the β- glucan-dependent, nonopsonic recognition of zymosan by primary macrophages. Zymosan is a yeast derived particle composed principally of polysaccharides, of which β-glucan and mannan are the major constituents. In vivo administration of zymosan, or purified soluble β-glucans, has a number of desirable effects on immune function, including the ability to confer resistance to tumors and various infections. The receptor is highly expressed on macrophages and neutrophils and to a lesser extent on dendritic cells and a subpopulation of T cells. Dectin-1 participates with the complement receptor CR3 in a host proinflammatory cytokine response to a fungal pathogen. The monoclonal antibody 2A11 recognizes an extracellular epitope on dectin-1.
Immunogen	NIH 3T3 cells transduced with full-length Dectin-1
Other Names	beta-glucan receptor
Gene, Accession #	n/a
Catalog #	HM1067
Price
Order / More Info	Dectin-1, Mouse Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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