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        產品名稱 Elafin, Human Antibody from HYCULT BIOTECH
        產品貨號 HM2062
        產品價格 現貨詢價,電話:010-67529703
        產品規(guī)格 100 μg
        產品品牌 HYCULT BIOTECH
        產品概述
        產品詳情
        Edit&nbsp
        Antigenic SpecificityElafin, Human
        CloneTRAB2O
        Host SpeciesMouse
        Reactive Specieshuman
        IsotypeIgG1
        Formatunconjugated
        Size100 μg
        Concentration100 μg/ml
        Applicationsimmunoassay, paraffin sections, WB
        Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
        DescriptionElafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to Elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to Elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that Elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria. TRAB2O recognises all known Trappins via the GQDPVK epitope. TRAB2O shows strong reaction with human native full-length Elafin/SKALP and a weaker reaction with fully processed Elafin/SKALP (C-terminal 57 aa). For detection of fully processed Elafin/SKALP (C-terminal 57 aa) we advise to use HM2063. The antibody is cross reactive with Trappin family members of other species with GQDPVK epitope.
        Immunogenn/a
        Other Namesn/a
        Gene, Accession #n/a
        Catalog #HM2062
        Price
        Order / More InfoElafin, Human Antibody from HYCULT BIOTECH
        Product Specific Referencesn/a
        產品資料
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