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產(chǎn)品名稱

EMAP-II, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM2185

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	EMAP-II, Human
Clone	546-2
Host Species	Mouse
Reactive Species	human, rat
Isotype	IgG2b
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	FC, immunoassay, paraffin sections, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Monoclonal antibody 546-2 reacts with endothelial-monocyte-activating polypeptide II (EMAP II), a 20 kDa polypeptide. EMAP II is an antiangiogenic and proinflammatory cytokine (expressed by microglia/macrophages). EMAP II appears to be a profound modulator of inflammatory reactions of the innate immune system and might participate in a variety of pathogenic immune-processes in the mammalian brain. EMAP II is a potential mediator of inflammatory responses in autoimmunity and a considered target to stage reactions of monocytic lineage cells in inflammatory reactions. In normal tissues EMAP II is expressed in endocrine organs, in cells of neuroendocrine origin, but also in tissues with high cell turnover. Under pathophysiological conditions EMAP II has several functions. It triggers the recruitment of macrophages by elevating cytosolic-free Ca2+ concentrations, it stimulates leukocyte chemotaxis, it induces the expression of TNF-alpha and tissue factor (TF) by monocytes and myeloperoxidase (MPO) by polymorphonuclear cells (PNMs). Furthermore it stimulates the release of von Willebrand-factor, P- and E-selectin by endothelial cells and EMAP II induces endothelial programmed cell death in vitro. The monoclonal antibody 546-2 is cross reactive with rat endothelial-monocyte-activating polypeptide II (rat EMAP II).
Immunogen	n/a
Other Names	n/a
Gene, Accession #	n/a
Catalog #	HM2185
Price
Order / More Info	EMAP-II, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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