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產(chǎn)品名稱(chēng)

Ficolin-1, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HP9039

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

50 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Ficolin-1, Human
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human
Isotype	n/a
Format	unconjugated
Size	50 μg
Concentration	50 μg/ml
Applications	FC, IF, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The polyconal antibody recognizes human Ficolin-1, also known as M-ficolin and ficolin/P35-related protein. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system, through association with MASPs, on the surface of microorganisms. In human, three Ficolins are known: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin), and Ficolin-3 (H-ficolin). Ficolin-1, is mainly expressed by monocytes, granulocytes and lung cells and is present locally in areas of inflammation. However, it was recently also found in serum suggesting that Ficolin-1 also has a role in systemic immunity like Ficolin-2 and Ficolin-3. Functional analysis of Ficolin-1 has demonstrated that it's ligand is sialic acid present on bacteria since binding was abolished by prior treatment of the bacteria with sialidase. Furthermore, it was shown that Ficolin-1 facilitates the uptake of E. coli by a leukemic monocyte lymphoma cell line, suggesting that it functions as a phagocytic receptor on the surface of circulating monocytes. Low cord blood concentration of Ficolin-1 has been associated with higher necrotizing enterocolitis-associated fatality and two identified SNPs in the Ficolin-1 gene are associated with the development of rheumatoid arthritis. Ficolin-1 has 75.3% amino acid identity with Ficolin-2 and 47.8% identity with Ficolin-3. Its mRNA is present in leukocytes and lung. Like its family members Ficolin-2 and Ficolin-3, Ficolin-1 is associated with MASPs and sMAP and activates the lectin pathway. The antibody to human Ficolin-1 is cross reactive with human Ficolin-2.
Immunogen	n/a
Other Names	n/a
Gene, Accession #	n/a
Catalog #	HP9039
Price
Order / More Info	Ficolin-1, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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