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產(chǎn)品名稱

Integrin alpha-IIb (CD41), Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM2343

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Integrin alpha-IIb (CD41), Human
Clone	Q9
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, paraffin sections, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Monoclonal antibody Q90 recognizes human CD41, also called ITGA2B, GPIIb or integrin alpha chain 2b. It is predominantly expressed on platelets and plays a pivotal role in coagulation. CD41 associates with integrin β3 chain (GPIIa or CD61) to form the CD41/CD61 complex. This complex is a receptor for fibrinogen, vWF, fibronectin, vitronectin, thrombospondin, prothrombin and thrombospondin. The integrin receptor is required for platelet adhesion and aggregation. Per platelet there are approximately 60-80 thousand copies of the complex. CD41 has been considered a biomarker for megakaryocytes. Although there is increasing evidence that it also expressed during early hematopoiesis with low expression levels on cells with myeloid and lymphoid potential. Given its central role in haemostasis it has been considered an anti-thrombotic target with alternating success. Mutations in the genes of the CD41/CD61 complex are a cause of Glanzmann thrombasthenia leading to bleeding disorders. Furthermore, there are some associations with tumor metastasis.
Immunogen	Synthetic CD41 peptide
Other Names	ITGA2B; GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41
Gene, Accession #	n/a
Catalog #	HM2343
Price
Order / More Info	Integrin alpha-IIb (CD41), Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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