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產(chǎn)品名稱

JAM-A, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM2099-FS

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

0.5 mg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	JAM-A, Human
Clone	M.Ab.F11
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	unconjugated
Size	0.5 mg
Concentration	100 μg/ml
Applications	FC, functional studies, IF, IP, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody M.Ab.F11 recognizes junctional adhesion molecule-A (JAM-A) also known as the human platelet F11-Receptor (F11R) and JAM-1 is a cell adhesion molecule (CAM). JAM-A is a member of the immunoglobulin superfamily found on the surface of human platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-A plays a role in platelet aggregation, secretion, adhesion, spreading. In the platelet F11R/JAM-A is a membrane protein involved in 2 distinct processes initiated on the platelet surface. Antibody-induced platelet aggregation and secretion both dependent on FcgammaRII and GPIIb/IIIa integrin, a process that may be involved in pathophysiological processes associated with certain thrombocytopenias. Antibody mediated platelet adhesion independent from FcgammaRII or fibrinogen receptor and that appears to play a role in physiological processes associated with platelet adhesion and aggregation. A physiological role for the F11R/JAM-A protein was demonstrated by its phosphorylation after the stimulation of platelets by thrombin and collagen. A pathophysiological role for the F11R/JAM-A was revealed by demonstrating the presence of F11R/JAM-A antibodies in patients with thrombocytopenia. Adhesion of platelets through the F11R resulted in events characteristic of the action of cell adhesion molecules (CAMs). Recent data suggests a role for F11R/JAM-A in the adhesion of platelets to cytokine-inflamed endothelial cells and thus in thrombosis and atherosclerosis induced in non-denuded blood vessels by inflammatory processes.
Immunogen	n/a
Other Names	n/a
Gene, Accession #	n/a
Catalog #	HM2099-FS
Price
Order / More Info	JAM-A, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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