| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | Nectin-3, Mouse |
|---|
| Clone | 13-A1 |
|---|
| Host Species | Rat |
|---|
| Reactive Species | mouse |
|---|
| Isotype | IgG2a |
|---|
| Format | unconjugated |
|---|
| Size | 100 μg |
|---|
| Concentration | 100 μg/ml |
|---|
| Applications | frozen sections, FC, functional studies, immunoassay, IF, IP |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Does not react with: human, rat. The monoclonal antibody 103-A1 recognizes mouse nectin-3. Nectin-3 is a 83 kDa type I transmembrane glycoprotein. Nectin, originally isolated as poliovirus receptor-related protein (PRR), is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectins are calciumindependent immunoglobulin-like cell-cell adhesion molecules consisting of four members, nectin 1-4. Nectins homophilically and heterophilically trans-interact to form a variety of cell-cell junctions, including cadherin-based adherens junctions in epithelial cells and fibroblasts in culture, synaptic junctions in neurons, and Sertoli cell-spermatid junctions in testis, in cooperation with, or independently of, cadherins. Both nectin-2 and nectin-3 are ubiquitously expressed, whereas nectin-1 is abundantly expressed in brain. Nectin-2 and -3 are expressed in cells where cadherin is not expressed, such as blood cells and spermatids. All members of the nectin family have two or three splice variants. For nectin-3, three isoforms exist: nectin-3α, -3β and -3g of which nectin-3α is the largest. Nectin-3, also known as PRR3, is a transmembrane protein that is predominantly expressed in testis and placental tissues as well in many cell lines. Nectin interacts in vivo with both long and short isoforms of afadin, an actin binding protein, at cadherin-based cell-cell adherence junctions in various tissues and cell lines. Furthermore, the ectodomains of nectin-3 and CD155 (Poliovirus Receptor) have shown strong affinity to each other. Injection of antibody 103-A1 into lumen of seminiferous tubules leads to disruption of the actin filaments in Sertoli cells at the Sertoli-maturing spermatid ectoplasmic specialization and exfoliation of maturing spermatids form the seminiferous epithelium. |
|---|
| Immunogen | Recombinant mouse nectin-3 extracellular domain (50-400 aa) fused to IgG Fc |
|---|
| Other Names | PPR3, poliovirus receptor-related protein 3, PRR3, PVRR3, CD113 |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HM1053 |
|---|
| Price | |
|---|
| Order / More Info | Nectin-3, Mouse Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
大吊无码,一级片免费看看,伊人久久99
|
婷婷综合无码,99re在线精品,女人高潮特黄AAAAA片
|
首页操逼网,生活一级片,91亚洲精品国偷拍自产在线观看
|
国内精品伊人久久,动漫做床爱大尺度电影,日本久久视频
|
996精品视频,美女黄18岁以下禁止观看,国产乱婬A∨片免费视频牛牛
爆操逼,美国一级大黄一片免费的网站,少妇精品视频
中文字幕一级A片,超薄肉色丝袜一区二区,黄色日逼一级视频
|
美女操逼电影,欧美一级片免费观看,日韩精品一区二区三区高清免费
|
国产中文,欧美午夜在线播放,国产av操逼
|
国产美女日逼视频,国产精品免费久久久久久久久,成人网免费观看
|
女女在线,一女被两男吃奶玩乳尖,aaa成人
|
2024亚洲男人天堂,在线免费观看污污视频,日韩免费一区二区在线观看
|
|