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        產(chǎn)品名稱 PAI-1, Human Antibody from HYCULT BIOTECH
        產(chǎn)品貨號(hào) HM2179
        產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià),電話:010-67529703
        產(chǎn)品規(guī)格 100 μg
        產(chǎn)品品牌 HYCULT BIOTECH
        產(chǎn)品概述
        產(chǎn)品詳情
        Edit&nbsp
        Antigenic SpecificityPAI-1, Human
        CloneMA-33H1F7
        Host SpeciesMouse
        Reactive Specieshuman, mouse, rabbit, rat
        IsotypeIgG1
        Formatunconjugated
        Size100 μg
        Concentration100 μg/ml
        Applicationsfunctional studies, immunoassay, WB
        Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
        DescriptionPlasminogen activator inhibitor type-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily, is an important protein in the regulation of fibrinolysis. PAI-1 is unique among the serpins because of its functional and conformational flexibility. PAI-1 is the most important physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u- PA). Increased PAI-1 levels are associated with thrombotic events and is an established risk factor for cardiovascular diseases. The active conformation PAI-1 inhibits its target proteinases by the formation of a stable, inactive complex. Although PAI-1 is synthesized as an active molecule, it converts spontaneously to an inactive, latent form that can be partially reactivated by denaturing agents. In addition, a third conformation reacting as a non-inhibitory substrate towards various target proteinases has been identified. The epitope of monoclonal antibody MA-33H1F7 is predominantly composed of three residues (Lys154/Glu130/Arg131), positioned virtually linearly in the three-dimensional structure. The epitope of the antibody does not cover the complete alpha-helix F and turn connecting alpha-helix F and beta-strand s3A, but is restricted to the hinge region between alpha-helix F and the main part of the PAI-1 molecule. The monoclonal antibody MA-33H1F7 is a `switching' antibody, capable of inducing a non-inhibitory substrate form of PAI-1. It was shown to inhibit PAI-1 in a dose dependent manner.
        ImmunogenHuman PAI-1/t-PA complex
        Other NamesPAI-1, endothelial plasminogen activator inhibitor, serpin E1
        Gene, Accession #n/a
        Catalog #HM2179
        Price
        Order / More InfoPAI-1, Human Antibody from HYCULT BIOTECH
        Product Specific Referencesn/a
        產(chǎn)品資料
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