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產(chǎn)品名稱

PAPC from HYCULT BIOTECH

產(chǎn)品貨號

HC4043

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

5 mg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	PAPC
Description	1-palmitoyl-2-arachidonoyl-sn-phosphatidylcholine (PAPC), is a naturally occuring phospholipid containing polyunsaturated arachidonic acid, which is a common lipid in mammalian cell membranes and lipoproteins. PAPC can be used as an unoxidized control in experiments utilizing oxidized PAPC (OxPAPC; cat. # HC4035/HC4036). OxPAPC, is a prototypic biologically active oxidized phospholipid first isolated from LDL minimally modified by oxidation (MM-LDL). OxPAPC is an active principle of MM-LDL and mimicks several pro- and anti-inflammatory effects induced by oxidized lipoproteins. Oxidation of PAPC generates two groups of oxidized phospholipids containing either fragmented or oxygenated sn-2 residues. The best-characterized fragmented species contain a five-carbon sn-2 residue bearing omega-aldehyde or omega-carboxyl groups. Oxygenation of arachidonic acid residue produces phospholipids containing esterified isoprostanes. Both fragmented and oxygenated species can regulate immune reactions. Pro-inflammatory effects of OxPAPC induce stimulation of endothelial cells to bind monocytes and induction of tissue clotting factor, IL-8, MCP-1, G-CSF and other mediators of atherothrombosis. Anti-inflammatory effects of OxPAPC are mediated by induction of protective enzymes such as heme oxygenase-1 and suppression of innate immune responses to bacterial lipopolysaccharide (LPS) due to inhibition of LPS recognition by LPS-binding protein (LBP) and CD14. OxPAPC is active in vivo and was shown to protect mice from lethal endotoxin shock. Biological activities of OxPAPC are mediated by a variety of signal transduction mechanisms, including elevation of cAMP and Ca2+ levels, activation of MAP kinases, PI-3-kinase and small GTPases Rac-1 and Cdc42. OxPAPC-induced protein synthesis is mediated by transcription factors such as Egr-1, NFAT, CREB, PPAR-alpha, PPAR-gamma, but does not involve NFkB-dependent transcription.
Size	5 mg
Concentration	5 mg dried synthetic PAPC, packed under argon.
Applications	n/a
Other Names	n/a
Gene, Accession, CAS #	n/a
Catalog #	HC4043
Price
Order / More Info	PAPC from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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