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| Antigenic Specificity | MAG |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human (predicted: bovine, monkey, rabbit) |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100ug (sample available) |
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| Concentration | 500ug/ml. |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit IgG polyclonal Picoband? antibody for Myelin-associated glycoprotein(MAG) detection. Tested with WB in Human. No cross reactivity with other proteins. MAG (Myelin-associated glycoprotein), also known as SIGLEC4A, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is thought to be involved in the process of myelination. The MAG gene is mapped on 19q13.12. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG. In cultured human embryonic kidney (HEK) cells expressing the NOGO receptor, p75(NTR) was required for MAG-induced intracellular calcium elevation. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human MAG (589-626aa EPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK), different from the related mouse sequence by one amino acid, and identical to the related rat sequence. |
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| Other Names | Myelin-associated glycoprotein;Siglec-4a;MAG;GMA; |
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| Gene, Accession # | MAG, UniProt: P20916 |
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| Catalog # | PB9809 |
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| Price | |
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| Order / More Info | MAG Antibody from BOSTER BIO |
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| Product Specific References | n/a |
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