| Description | Cellular oxidative and electrophilic stress caused by drugs and other xenobiotics, inflammation, and ionizing radiation are associated with an accumulation of reactive oxygen species and electrophilic insults, which contribute to the pathogenesis of various diseases such as cancer, neurodegenerative disease, and atherosclerosis. In order to protect cells from reactive oxygen species and electrophilic insults, the endogenous cellular antioxidant defense system initiates a response to cellular oxidative and electrophilic stress. NRF2 (nuclear factor (erythroid-derived 2)-like 2; NFE2L2) is a key transcriptional factor regulating hundreds of antioxidant and Phase II detoxification genes. Under normal conditions, NRF2 is sequestered in the cyto |
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