| 產(chǎn)品詳情 |
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| Antigenic Specificity | CCND1 |
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| Clone | RM241 |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | Protein A purified |
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| Size | 50 μl |
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| Concentration | n/a |
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| Applications | IHC, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit monoclonal antibody to detect Cyclin D1 in human samples. Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. |
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| Immunogen | A peptide corresponding to Cyclin D1 |
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| Other Names | G1/S-specific cyclin-D1, B-cell lymphoma 1 protein, BCL-1, PRAD1 |
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| Gene, Accession # | Gene ID: 595, Accession: P24385 |
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| Catalog # | A1129-50 |
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| Price | |
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| Order / More Info | CCND1 Antibody from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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