| 產(chǎn)品詳情 |
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| Antigenic Specificity | ORAI1 |
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| Clone | 3F6H5 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 μg/mL, Immunofluorescence: 20 μg/mL, Immunohistochemistry: 2.5 μg/mL, Western Blot: 1-2 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ORAI1 Monoclonal Antibody (3F6H5). Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | Entrez: 109305, 304496, 84876; Uniprot: Q5M848, Q8BWG9, Q96D31 |
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| Catalog # | MA5-15776 |
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| Price | |
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| Order / More Info | ORAI1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 27641745 |
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