| 產(chǎn)品詳情 |
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| Antigenic Specificity | N4BP2L2 |
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| Clone | OTI1C8 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 μl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:200 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | N4BP2L2 Monoclonal Antibody (OTI1C8). N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that potentially is involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is dramatically down-regulated after exposure to arsenic compounds, an event which precedes neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins that are implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase, ELA2, are the cause of cyclic haematopoiesis, which, with decreased numbers of circulating neutrophil |
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| Immunogen | n/a |
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| Other Names | NEDD4-binding protein 2-like 2, Phosphonoformate immuno-associated protein 5, CG005, PFAAP5 |
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| Gene, Accession # | Entrez: 10443; Uniprot: Q92802 |
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| Catalog # | MA5-26655 |
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| Price | |
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| Order / More Info | N4BP2L2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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