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| Antigenic Specificity | IRS1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Western Blot: 1:250 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IRS1 Polyclonal Antibody. Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic option. To date there have been four subtypes identified: IRS-1,2,3, and 4, with IRS-1 be |
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| Immunogen | n/a |
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| Other Names | Insulin Receptor Substrate-1 |
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| Gene, Accession # | Entrez: 16367, 3667; Uniprot: P35568, P35569 |
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| Catalog # | PA1-1057 |
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| Price | |
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| Order / More Info | IRS1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15536073, 25402228 |
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