| 產(chǎn)品詳情 |
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| Antigenic Specificity | IRS1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2 μg/mL, Immunofluorescence: 2 μg/mL, Western Blot: 1-4 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IRS1 Polyclonal Antibody. Following tyrosine phosphorylation, the insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) can form a protein scaffolding for the assembly of a host of Src homology 2 (SH2) domain-containing proteins. IRS-1 tyrosine phosphorylation can occur through the activity of several cytokine and growth factor receptors such as interleukin (IL)-4, IL-9, interferon-gamma, in addition to the insulin and insulin-like growth factor 1 receptors. The scaffolding provided by IRS-1 and IRS-2 is necessary for insulin signal transduction across the cell membrane. IRS-1 tyrosine phosphorylation, and thus formation of the IRS scaffolding is inhibited by tumor necrosis factor (TNF), and this inhibition can itself be blocked by rapamycin |
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| Immunogen | n/a |
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| Other Names | HIRS-1; IRS-1 |
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| Gene, Accession # | Entrez: 16367, 3667; Uniprot: P35568, P35569 |
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| Catalog # | PA5-20137 |
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| Price | |
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| Order / More Info | IRS1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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