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產(chǎn)品名稱

MIP-3α/CCL20 Antibody from DENDRITICS SAS

產(chǎn)品貨號

DDX0420

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100μg/50μg

產(chǎn)品品牌

DENDRITICS SAS

產(chǎn)品概述

產(chǎn)品詳情

Edit	&nbsp
Antigenic Specificity	MIP-3α/CCL20
Clone	206D9.05
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	purified
Size	100μg/50μg
Concentration	n/a
Applications	Blocking migration of DCs, IHC bouin paraffin, frozen section, ELISA detection
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Macrophage inflammatory protein (MIP)-3alpha/ CCL20 is a CC-type chemokine mapped to chromosome 2 in humans. Langerhans cells (LCs) represent a unique population of DCs colonizing epithelium. MIP-3alpha plays a central role in LC precursor recruitment into the epithelium during inflammation. (a) Among DC populations, MIP-3alpha is the most potent chemokine inducing the selective migration of in vitro-generated CD34(+) hematopoietic progenitor cell-derived LC precursors and skin LCs in accordance with the restricted MIP-3alpha receptor (CC chemokine receptor 6) expression by these cells. (b) MIP-3alpha is mainly produced by epithelial cells, and the migration of LC precursors induced by the supernatant of activated skin keratinocytes is blocked with an antibody against MIP-3alpha. (c) In vivo, MIP-3alpha is selectively produced at sites of inflammation as illustrated in tonsils and lesional psoriatic skin where MIP-3alpha upregulation appear associated with an increase in LC turnover. (d) The secretion of MIP-3alpha is strongly upregulated by cells of epithelial origin after inflammatory stimuli (interleukin 1beta plus tumor necrosis factor alpha) or T cell signals.(Dieu-Nosjean et al, J;Exp.med, 2000 192: 705-18)
Immunogen	n/a
Other Names	Macrophage inflammatory protein (MIP)-3alpha/ CCL20
Gene, Accession #	n/a
Catalog #	DDX0420
Price
Order / More Info	MIP-3α/CCL20 Antibody from DENDRITICS SAS
Product Specific References	n/a
產(chǎn)品資料

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