| 產(chǎn)品詳情 |
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| Antigenic Specificity | Interleukin 17A (IL17A) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC),Immunofluorescence (IF) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage. IL-17A stimulates the production of the pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity. IL-17A is intimately involved in mucosal immunity against bacterial infections and has a putative role in some autoimmune disorders. IL-17A effects appear to be exerted primarily through binding to the IL-17RA. IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1/2 MAP kinase, PI3K/Akt, p38, and NF-kappaB pathways (3, 4, 6). Phosphorylation of some Jaks and Stats has been observed.Synonyms: IL17A, CTLA8, IL-17, IL-17A, IL17 |
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| Immunogen | Recombinant protein of human IL17A |
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| Other Names | Il17|IL17A|CTLA8|IL-17|IL-17A|IL17|Ctla-8|Ctla8|CTLA-8|ChIL-17|IL-17F |
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| Gene, Accession # | Gene ID: 3605,16171,301289 |
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| Catalog # | ABIN1513080 |
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| Price | |
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| Order / More Info | Interleukin 17A (IL17A) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 24928352, 25111887 |
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