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| Antigenic Specificity | CD152 |
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| Clone | 9H10 |
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| Host Species | Syrian Hamster |
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| Reactive Species | mouse |
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| Isotype | IgG |
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| Format | purified |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | ELISA, Flow Cytometry (FC), Block, Costim |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GoInVivo? Purified anti-mouse CD152. CD152 is a 33 kD member of the immunoglobulin superfamily also known as CTLA-4 or Ly-56. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance, as well as the development of protective immunity and thymocyte regulation. The 9H10 antibody can enhance T cell co-stimulation by blocking CTLA-4 interactions with the B7 co-receptors, favoring CD28 interactions. |
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| Immunogen | Mouse CTLA-4-human IgG1 fusion protein |
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| Other Names | Cytotoxic T Lymphocyte-Associated Antigen-4, CTLA-4, Ly-56 |
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| Gene, Accession # | Gene ID: 12477 |
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| Catalog # | 106206 |
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| Price | |
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| Order / More Info | CD152 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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