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        產品名稱 Granzyme B Antibody from BIOLEGEND
        產品貨號 674602
        產品價格 現貨詢價,電話:010-67529703
        產品規(guī)格 100 μg
        產品品牌 BIOLEGEND
        產品概述
        產品詳情
        Edit&nbsp
        Antigenic SpecificityGranzyme B
        CloneM3304B06
        Host SpeciesMouse
        Reactive Specieshuman
        IsotypeIgG1
        Formatpurified
        Size100 μg
        Concentrationn/a
        ApplicationsWestern Blot (WB)
        Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
        DescriptionPurified anti-Granzyme B. Granzyme B is a serine protease that is mainly produced by cytotoxic T cells (CTL) and NK cells. It plays important roles in cytotoxic lymphocyte-mediated apoptosis, chronic inflammation, and impaired wound healing. Granzyme B is packaged in cytoplasmic granules that are exocytosed towards a bound target cell, and subsequently activates multiple protein substrates to induce apoptosis. Perforin facilitates the transfer of Granzyme B into the target cell. Most circulating CD56+ CD8- NK cells and approximately half of circulating CD8+ T cells coexpress both Granzyme A and B. The activation of CD8+ and CD4+ T lymphocytes induces substantial expression of Granzyme B, but not Granzyme A. Recently, Granzyme B has been found to be produced by other cell types such as CD34+ hematopoietic progenitor cells, keratinocytes, basophils, mast cells, plasmacytoid dendritic cells, B cells, and smooth muscle cells. Elevated levels of Granzyme B are also found in some kinds of autoimmune diseases, type 1 diabetes, and cardiovascular diseases.
        ImmunogenRecombinant human Granzyme B produced in the 293E cell line.
        Other NamesGranzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1, GZMB, CCP1, Asp-ase, CSPB, CTLA-1, CGL-1, CGL1
        Gene, Accession #Gene ID: 3002
        Catalog #674602
        Price
        Order / More InfoGranzyme B Antibody from BIOLEGEND
        Product Specific Referencesn/a
        產品資料
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