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| Antigenic Specificity | NEFH/NEFM/NEFL |
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| Clone | RMdO-20 |
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| Host Species | Mouse |
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| Reactive Species | bovine, hamster, human, mollusca, mouse, rabbit, rat |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 200 μg |
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| Concentration | n/a |
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| Applications | ELISA: 0.1-0.5 μg/mL, Immunocytochemistry: 1:20, Immunofluorescence: 1:20, Immunohistochemistry: 1:20, Immunoprecipitation: 2-5 μg, Western Blot: 0.5-2 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | NEFH/NEFM/NEFL Monoclonal Antibody (RMdO-20). Neurofilaments are the intermediate (10-12 nm) filament proteins (IFPs) located specifically in neurons, and are composed predominantly of three classes/subunits of neurofilaments: NF-L (low molecular weight; 68 kDa), NF-M (medium molecular weight; 160 kDa), and NF-H (high molecular weight; 200 kDa), with some variation in different species. The neurofilaments are long helical proteins involved in the maintenance of neuronal caliber, which polymerize to form a rigid cytoskeleton in the neuron. Like most other IFPs, the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. This polymerized network is composed of all three filaments, and the stoichiometry |
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| Immunogen | n/a |
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| Other Names | NEFM; neurofilament medium polypeptide; NEF3; NF-M; NFM; neurofilament triplet M protein; neurofilament medium polypeptide 150kDa; neurofilament-3, NFH, NF-H, NHC, 200 kDa neurofilament protein, KIAA0845, Neurofilament heavy polypeptide, Neurofilament triplet H protein, NFL, NF-L, NLC, 68 kDa neurofilament protein, 70 kDa neurofilament protein, CMT1F, CMT2E, Neurofilament light polypeptide, neurofilament medium, neurofilament light, neurofilament heavy |
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| Gene, Accession # | Entrez: 100009343, 100353082, 100357177, 101830604, 101838568, 106021552, 18039, 18040, 24587, 24588, 281347, 281348, 380684, 4741, 4744, 4747, 528842, 83613; Uniprot: O77788, P02548, P07196, P07197, P08551, P08553, P12036, P12839, P16884, P19246, P19527, P54938 |
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| Catalog # | 13-1300 |
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| Price | |
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| Order / More Info | NEFH/NEFM/NEFL Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 12782575, 12925276, 15078815, 15105808, 17240155, 24612193, 27015737 |
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