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| Antigenic Specificity | RUSC1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1-4 μg/mL, Immunofluorescence: 1-4 μg/mL, Immunohistochemistry: 1:50-1:200, Western Blot: 0.4 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RUSC1 Polyclonal Antibody. RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Ikappa-B kinase- (IKK-) -gamma, the regulatory subunit of the IKK complex that is required for NF-kappa-B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, |
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| Immunogen | n/a |
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| Other Names | RP11-21N7.4, NESCA; RUN and SH3 domain-containing protein 1; new molecule containing SH3 at the carboxy-terminus |
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| Gene, Accession # | Entrez: 23623, 72296; Uniprot: Q8BG26, Q9BVN2 |
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| Catalog # | PA5-55885 |
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| Price | |
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| Order / More Info | RUSC1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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