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| Antigenic Specificity | NALP12 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:50-1:200 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | NALP12 Polyclonal Antibody. NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes. |
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| Immunogen | n/a |
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| Other Names | CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2; NACHT, LRR and PYD containing protein 12; NACHT, LRR and PYD domains-containing protein 12; NACHT, leucine rich repeat and PYD containing 12; PYRIN-containing APAF1-like protein 7; monarch 1; monarch-1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; regulated by nitric oxide |
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| Gene, Accession # | Entrez: 91662; Uniprot: P59046 |
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| Catalog # | PA5-60185 |
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| Price | |
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| Order / More Info | NALP12 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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