| Edit |   |
|---|
| Antigenic Specificity | NALP12 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 50 μL |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:1000-1:5000, Immunoprecipitation: 1:50-1:200, Western Blot: 1:1000-1:2000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | NALP12 Polyclonal Antibody. NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes. |
|---|
| Immunogen | n/a |
|---|
| Other Names | CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2; NACHT, LRR and PYD containing protein 12; NACHT, LRR and PYD domains-containing protein 12; NACHT, leucine rich repeat and PYD containing 12; PYRIN-containing APAF1-like protein 7; monarch 1; monarch-1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; regulated by nitric oxide |
|---|
| Gene, Accession # | Entrez: 91662; Uniprot: P59046 |
|---|
| Catalog # | PA5-72911 |
|---|
| Price | |
|---|
| Order / More Info | NALP12 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|