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| Antigenic Specificity | SQSTM1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Western Blot: 1:1000-1:10,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SQSTM1 Polyclonal Antibody. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD . May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. |
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| Immunogen | n/a |
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| Other Names | A170, OSIL, PDB3, ZIP3, p60, p62, p62B |
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| Gene, Accession # | Entrez: 8878; Uniprot: Q13501 |
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| Catalog # | PA5-34781 |
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| Price | |
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| Order / More Info | SQSTM1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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