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| Antigenic Specificity | RANK |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot: 1-3 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RANK Polyclonal Antibody. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathway. Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2. |
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| Immunogen | n/a |
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| Other Names | FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER, TNFRSF11A |
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| Gene, Accession # | Entrez: 21934, 8792; Uniprot: O35305, Q9Y6Q6 |
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| Catalog # | PA1-41389 |
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| Price | |
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| Order / More Info | RANK Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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