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產(chǎn)品名稱

CD171 Antibody from BIOLEGEND

產(chǎn)品貨號(hào)

686102

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	CD171
Clone	O92G9
Host Species	Mouse
Reactive Species	human
Isotype	IgG1, κ
Format	purified
Size	100 μg
Concentration	n/a
Applications	Western Blot (WB), Immunofluorescence Microscopy (IF)
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Purified anti-CD171 (L1CAM). L1CAM is a 200–220 kD transmembrane glycoprotein of the immunoglobulin (Ig) superfamily. It is composed of 6 Ig-like domains and 5 fibronectin type III repeats followed by a transmembrane region and a highly conserved cytoplasmic tail. The members of the L1 family are L1-CAM (CD171), close homolog of L1-CAM (CHL1), neurofascin (NFASC) and NgCAM related cell adhesion molecule (NR-CAM). L1CAM can bind to itself (homophilic) or heterophilically to other neural cell adhesion molecules, integrins, CD24, neurocan and neuropilin-1. The cytoplasmic tail of L1CAM can interact with the cytoskeletal proteins ankyrin, actin, spectrin and ERM proteins. L1CAM was discovered as a cell adhesion molecule in the nervous system. During brain development, L1CAM is involved in neurite outgrowth and fasciculation, as well as adhesion and migration. In addition, L1CAM participates in myelination processes by mediating the elongation of Schwann cells along the axon and promotes neural cell survival. Mutations of the L1CAM gene cause severe recessive cerebral disorders like X-linked mental retardation and schizophrenia and frequently lead to neonatal death. L1CAM is overexpressed in many human cancers, such as ovarian and endometrial carcinoma, pancreatic cancer, melanoma and glioblastoma. L1CAM expression is usually associated with poor prognosis, an aggressive phenotype, and advanced tumor stages. Unlike in neural cells, L1CAM in the tumor setting rarely promotes static cell-cell adhesion, but induces a motile and invasive phenotype, supporting an aggressive tumor growth, metastasis and chemoresistance.
Immunogen	Full-length recombinant human CD171 produced in 293T cells.
Other Names	L1CAM, Neural cell adhesion molecule L1, NCAM-L1
Gene, Accession #	Gene ID: 3897
Catalog #	686102
Price
Order / More Info	CD171 Antibody from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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