| 產(chǎn)品詳情 |
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| Antigenic Specificity | CD279 (PD-1) |
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| Clone | EH12.2H7 |
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| Host Species | Mouse |
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| Reactive Species | human, African green, baboon, chimpanzee, common marmoset, cynomolgus, rhesus, squirrel monkey |
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| Isotype | IgG1, κ |
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| Format | purified, azide-free |
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| Size | 500 μg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), Block, IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LEAF? Purified anti-human CD279 (PD-1). Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
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| Immunogen | n/a |
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| Other Names | PD-1 |
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| Gene, Accession # | Gene ID: 5133 |
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| Catalog # | 329912 |
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| Price | |
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| Order / More Info | CD279 (PD-1) Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 18829748,18981087,19553327,19889785,20100932,21398606,21562156 |
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