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產(chǎn)品名稱

IL3R α/ CD123 Antibody from DENDRITICS SAS

產(chǎn)品貨號(hào)

DDX0301

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100μg/50μg

產(chǎn)品品牌

DENDRITICS SAS

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	IL3R α/ CD123
Clone	106C2.02
Host Species	Mouse
Reactive Species	human, swine
Isotype	IgG1
Format	purified
Size	100μg/50μg
Concentration	n/a
Applications	FACS surface, IF, IHC
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	IL-3 exerts its biologic activity (eg survival and proliferation of multipotent hematopoietic cells, development of pDCs) through its interaction with a cell surface receptor that consists of two subunits. The α subunit (CD123) specifically binds IL-3, whereas the ??subunit is required for signaling and is common to the GMCSF-R and IL-5-R. Interplay of α and ??chains leads to the formation of a high-affinity receptor complex able to transduce proliferative, apoptotic and differentiative signals. Plasmacytoid DCs express IL3-R and differentiate into functional DCs with IL-3. The leukemic pDC counterpart also expresses high levels of IL3-Rα. Upon IL-3 treatment in vitro, leukemic cells become inducers of T-cell proliferation, as reported for normal pDCs.The role of IL3-R in oncogenesis has been explored in several animal models. Overexpression of the IL3-R ? chain may represent one of the mechanisms contributing to the development of a highly malignant leukemic phenotype. Treilleux I et al., 2004, Clinical Cancer Research, 10: 7466-7474,
Immunogen	n/a
Other Names	interleukin
Gene, Accession #	n/a
Catalog #	DDX0301
Price
Order / More Info	IL3R α/ CD123 Antibody from DENDRITICS SAS
Product Specific References	n/a
產(chǎn)品資料

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