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產(chǎn)品名稱

TLR3/CD283 Antibody from DENDRITICS SAS

產(chǎn)品貨號(hào)

DDX0475

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100μg/50μg

產(chǎn)品品牌

DENDRITICS SAS

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	TLR3/CD283
Clone	716G10.15
Host Species	Mouse
Reactive Species	human, rat, mouse, dog, sheep
Isotype	IgM
Format	purified
Size	100μg/50μg
Concentration	n/a
Applications	IHC frozen section, bouin paraffin, FACS intracyto
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The Toll-like receptor (TLR) family has recently emerged as key for sensing microbial infections and triggering inflammatory and innate responses. Ten TLRs have been cloned in humans. They share structural and functional homologies, as they are all able to detect micro-organisms through direct recognition of conserved Pathogen Associated Molecular Patterns (PAMPs) such as bacterial lipopolysaccharide (LPS) or viral double stranded RNA (dsRNA). Ligand recognition is mediated through the C-terminal Leucine Rich Repeat region, while signalling involves the N-terminal Toll/Interleukin-1 Receptor (TIR) domain. TLR3 has been identified as a receptor for dsRNA. Unlike other TLRs, the cytoplasmic tail of TLR3 does not contain a conserved proline residue, whose mutation confers LPS unresponsiveness in C3H/HeJ mice. TLR3 is the only TLR that signals exclusively through the TIR?containing adaptor TRIF (TIR?containing adaptor inducing IFNβ), which activates the transcription factors IRF3 and NFκB, and triggers type I interferon secretion. TLR3 is expressed in various cell types, such as fibroblasts, dendritic cells (DCs), or NK cells. While TLR3 is expressed at the cell surface in fibroblasts, it is mostly found in intracytoplasmic vesicles in DCs.
Immunogen	n/a
Other Names	Toll-like receptor 3
Gene, Accession #	n/a
Catalog #	DDX0475
Price
Order / More Info	TLR3/CD283 Antibody from DENDRITICS SAS
Product Specific References	n/a
產(chǎn)品資料

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